Coronary Artery Disease (CAD) and Atherosclerosis

Coronary Artery Disease (CAD) is a condition where the blood vessels supplying the heart muscle become narrowed or blocked due to the buildup of plaque, a fatty substance. This plaque accumulation, known as atherosclerosis, restricts blood flow to the heart, leading to chest pain (angina) or potentially causing heart attacks. Atherosclerosis involves the gradual deposition of cholesterol, inflammatory cells, and other materials within the arterial walls. As the plaque grows, it can limit the supply of oxygen and nutrients to the heart muscle. Understanding the mechanisms of CAD and atherosclerosis is crucial for developing effective prevention strategies and innovative treatments, ranging from lifestyle changes and medications to interventional procedures like stents and bypass surgeries.

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